Pub. Date : 2011 Apr 20
PMID : 21508279
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Doxorubicin treatment increased the expression of Bcl-2, an anti-apoptotic protein, but this upregulation was blocked by combined treatment with PD98059, suggesting a role for ERK1/2 in conferring drug resistance. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | mitogen-activated protein kinase 3 | Mus musculus |
| 2 | In osteosarcoma-bearing mice, targeting ERK1/2 with PD98059 resulted in prolonged survival in comparison with vehicle-treated control mice (median survival time, sixty-seven days compared with seventy-four days; p = 0.0272; survival ratio = 0.9122; 95% confidence interval = 0.4354 to 1.389). | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | mitogen-activated protein kinase 3 | Mus musculus |