Pub. Date : 2011 Jul
PMID : 21503676
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Blocking caspase-3-dependent pathway preserves hair cells from salicylate-induced apoptosis in the guinea pig cochlea. | Salicylates | caspase-3 | Cavia porcellus |
| 2 | In the present study, we aim to explore whether the caspase-3-dependent pathway is involved in the apoptotic cell death that occurs in the hair cells (HCs) of guinea pig cochlea following a salicylate treatment. | Salicylates | caspase-3 | Cavia porcellus |
| 3 | Salicylate treatment initiated an obvious elevation in ABR thresholds with a maximum average shift of 60 dB sound pressure level (SPL), and caused significant apoptosis in both inner (IHCs) and outer (OHCs) hair cells resulted from an evident increasing in immunoreactivity to caspase-3 protease. | Salicylates | caspase-3 | Cavia porcellus |
| 4 | These findings indicate that salicylate could damage cochlear hair cells via inducing apoptosis associated with caspase-3 activation. | Salicylates | caspase-3 | Cavia porcellus |