Pub. Date : 2011 Jul
PMID : 21503567
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dihydrotestosterone induces p27 degradation via direct binding with SKP2 in ovarian and breast cancer. | Dihydrotestosterone | zinc ribbon domain containing 2 | Homo sapiens |
| 2 | We found that DHT could down-regulate p27, but not p21, within 4 h. Further studies proved that DHT induced p27 degradation through the ubiquitin-proteasome proteolytic pathway. | Dihydrotestosterone | zinc ribbon domain containing 2 | Homo sapiens |
| 3 | We found that DHT could down-regulate p27, but not p21, within 4 h. Further studies proved that DHT induced p27 degradation through the ubiquitin-proteasome proteolytic pathway. | Dihydrotestosterone | zinc ribbon domain containing 2 | Homo sapiens |
| 4 | We found that DHT could down-regulate p27, but not p21, within 4 h. Further studies proved that DHT induced p27 degradation through the ubiquitin-proteasome proteolytic pathway. | Dihydrotestosterone | zinc ribbon domain containing 2 | Homo sapiens |
| 5 | We found that DHT could down-regulate p27, but not p21, within 4 h. Further studies proved that DHT induced p27 degradation through the ubiquitin-proteasome proteolytic pathway. | Dihydrotestosterone | zinc ribbon domain containing 2 | Homo sapiens |
| 6 | However, proteolysis inhibitors effectively antagonized the DHT-induced p27 degradation. | Dihydrotestosterone | zinc ribbon domain containing 2 | Homo sapiens |
| 7 | DHT led to the direct binding of p27 to SKP2 independent of the phosphorylation status. | Dihydrotestosterone | zinc ribbon domain containing 2 | Homo sapiens |
| 8 | Collectively, DHT, but not the other examined androgens regulated the degradation of p27 in MCF-7 and OVCAR-3 cells. | Dihydrotestosterone | zinc ribbon domain containing 2 | Homo sapiens |