Title : The influence of manipulations to alter ambient GABA concentrations on the hypnotic and immobilizing actions produced by sevoflurane, propofol, and midazolam.

Pub. Date : 2011 Jul-Aug

PMID : 21497611






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Two manipulations studied were 1) the genetic absence of glutamate decarboxylase (GAD) 65 gene (GAD65-/-), which purportedly reduced ambient GABA concentrations, and 2) the pharmacological manipulation of GABA uptake using GABA transporter inhibitor (NO-711). gamma-Aminobutyric Acid glutamic acid decarboxylase 2 Mus musculus
2 Two manipulations studied were 1) the genetic absence of glutamate decarboxylase (GAD) 65 gene (GAD65-/-), which purportedly reduced ambient GABA concentrations, and 2) the pharmacological manipulation of GABA uptake using GABA transporter inhibitor (NO-711). gamma-Aminobutyric Acid glutamic acid decarboxylase 2 Mus musculus
3 HPLC revealed that GABA levels in GAD65-/- mice were reduced in the brain (76.7% of WT) and spinal cord (68.5% of WT). gamma-Aminobutyric Acid glutamic acid decarboxylase 2 Mus musculus