Title : Piceatannol inhibits migration and invasion of prostate cancer cells: possible mediation by decreased interleukin-6 signaling.

Pub. Date : 2012 Mar

PMID : 21497499






3 Functional Relationships(s)
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1 In DU145 cells, piceatannol attenuated the secretion and messenger RNA levels of matrix metalloproteinase-9, urokinase-type plasminogen activator (uPA) and vascular endothelial growth factor (VEGF). 3,3',4,5'-tetrahydroxystilbene vascular endothelial growth factor A Homo sapiens
2 In DU145 cells, piceatannol attenuated the secretion and messenger RNA levels of matrix metalloproteinase-9, urokinase-type plasminogen activator (uPA) and vascular endothelial growth factor (VEGF). 3,3',4,5'-tetrahydroxystilbene vascular endothelial growth factor A Homo sapiens
3 Interleukin-6 treatment was also shown to enhance the secretion of uPA and VEGF, STAT3 phosphorylation and the migration of DU145 cells; these increases were suppressed by piceatannol. 3,3',4,5'-tetrahydroxystilbene vascular endothelial growth factor A Homo sapiens