Title : Ursolic acid attenuates lipopolysaccharide-induced cognitive deficits in mouse brain through suppressing p38/NF-κB mediated inflammatory pathways.

Pub. Date : 2011 Sep

PMID : 21496491






1 Functional Relationships(s)
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1 Mechanistically, UA markedly inhibited LPS-induced IkappaBalpha phosphorylation and degradation, NF-kappaB p65 nuclear translocation and p38 activation in mouse brain, but did not affect the activation of TLR4, MyD88, ERK, JNK and Akt. ursolic acid thymoma viral proto-oncogene 1 Mus musculus