Title : Effect of inhibition of the ubiquitin-proteasome-system and IκB kinase on airway inflammation and hyperresponsiveness in a murine model of asthma.

Pub. Date : 2011 Jan-Mar

PMID : 21496385






2 Functional Relationships(s)
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1 In contrast, treatment of mice with the IKK inhibitor, BAY 11-7085, (3 and 10 mg/kg) dose-dependently inhibited the ovalbumin-induced increase in airway leukocyte influx and decreased the percentage of airway lymphocytes, neutrophils and eosinophils. BAY 11-7085 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus
2 Furthermore, BAY 11-7085 significantly inhibited the ovalbumin-induced increase in the level of phosphorylation of IkBalpha and extracellular regulated kinases (ERK) 1/2, whilst MG-132 significantly increased the phosphorylation of (ERK) 1/2. BAY 11-7085 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus