Pub. Date : 2011 Jun
PMID : 21492194
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Robenacoxib in the dog: target species safety in relation to extent and duration of inhibition of COX-1 and COX-2. | robenacoxib | cytochrome c oxidase subunit I | Canis lupus familiaris |
| 2 | For the highest dosage of robenacoxib (40 mg/kg in Study 1), the upper limit of the 90% tolerance interval was associated with 71% inhibition of COX-1 at Emax, but 50% inhibition persisted for only 3.5 h. This level of inhibition of COX-1 with robenacoxib was not associated with any detectable toxicity, suggesting that the high safety index of robenacoxib in dogs is a function of both its high COX-2 selectivity and short residence time in the central compartment. | robenacoxib | cytochrome c oxidase subunit I | Canis lupus familiaris |
| 3 | For the highest dosage of robenacoxib (40 mg/kg in Study 1), the upper limit of the 90% tolerance interval was associated with 71% inhibition of COX-1 at Emax, but 50% inhibition persisted for only 3.5 h. This level of inhibition of COX-1 with robenacoxib was not associated with any detectable toxicity, suggesting that the high safety index of robenacoxib in dogs is a function of both its high COX-2 selectivity and short residence time in the central compartment. | robenacoxib | cytochrome c oxidase subunit I | Canis lupus familiaris |