Title : Developmental GABAergic deficit enhances methamphetamine-induced apoptosis.

Pub. Date : 2011 Jun

PMID : 21487660






1 Functional Relationships(s)
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1 RESULTS: Offspring of dams exposed to NMDA receptor antagonist MK-801 on days 15-18 of pregnancy (MK-801 offspring) showed reduced density of parvalbumin-immunoreactive GABAergic interneurons in the mPFC, PPI disruption on postnatal days 63 (P63) and 35 (P35) and an enhanced METH (2.5 mg/kg)-induced glutamate release. Methamphetamine parvalbumin Rattus norvegicus