Pub. Date : 2012 Jan
PMID : 21484968
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | METHODS: Here we investigated the role of lumican in the development of colitis mediated by intrarectal administration of the hapten 2-4-5, trinitrobenzene sulfonic acid (TNBS) in Lum(+/+) and Lum(-/-) mice. | Trinitrobenzenesulfonic Acid | lumican | Mus musculus |
| 2 | RESULTS: The TNBS treated Lum(+/+) mouse colons showed marked increases in CXCL1, tumor necrosis factor alpha (TNF-alpha), and neutrophil infiltration, whereas these responses were significantly dampened in the Lum(-/-) mice. | Trinitrobenzenesulfonic Acid | lumican | Mus musculus |
| 3 | RESULTS: The TNBS treated Lum(+/+) mouse colons showed marked increases in CXCL1, tumor necrosis factor alpha (TNF-alpha), and neutrophil infiltration, whereas these responses were significantly dampened in the Lum(-/-) mice. | Trinitrobenzenesulfonic Acid | lumican | Mus musculus |
| 4 | The nuclear factor kappa B (NF-kappaB) transcription factor, known to regulate inflammatory genes, showed a robust increase after TNBS treatment in Lum(+/+) but not in Lum(-/-) colons. | Trinitrobenzenesulfonic Acid | lumican | Mus musculus |