Title : Taurine protects rat testes against doxorubicin-induced oxidative stress as well as p53, Fas and caspase 12-mediated apoptosis.

Pub. Date : 2012 May

PMID : 21476075






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1 Rats treated with doxorubicin alone displayed reduced body and testicular weights, decreased sperm counts, increased the extent of testicular toxicity (as evident from the decreased activity of testicular marker enzyme, SDH) and oxidative stress (reduced GSH, increased GSSG and MDA levels), decreased antioxidant (SOD, CAT, GST, GPx, GR) and membrane-bound (Na+-K+ and Ca2+ ATPases) enzyme activities as well as plasma testosterone. Doxorubicin catalase Rattus norvegicus