Title : The cyclooxygenase-2 inhibitor celecoxib attenuates hepatocellular carcinoma growth and c-Met expression in an orthotopic mouse model.

Pub. Date : 2011

PMID : 21473289






2 Functional Relationships(s)
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1 Significant increases in body weight were observed in celecoxib- or doxorubicin-treated mice compared to saline-treated animals and tumor growth was significantly attenuated, accompanied by downregulation of tumor PCNA expression (p < 0.01). Celecoxib proliferating cell nuclear antigen Mus musculus
2 Celecoxib also inhibited tumor cell PCNA expression independent of changes in c-Met expression, with some variability between different implanted cell lines. Celecoxib proliferating cell nuclear antigen Mus musculus