Title : Cot/tpl2 activity is required for TLR-induced activation of the Akt p70 S6k pathway in macrophages: Implications for NO synthase 2 expression.

Pub. Date : 2011 Jun

PMID : 21469113






1 Functional Relationships(s)
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1 Furthermore, in zymosan- and polyI:C-stimulated macrophages, Cot/tpl2 mediates P-Ser473 Akt phosphorylation, increases IkappaBalpha levels and decreases NOS2 expression. Carbon mitogen-activated protein kinase kinase kinase 8 Homo sapiens