Title : Bortezomib primes neuroblastoma cells for TRAIL-induced apoptosis by linking the death receptor to the mitochondrial pathway.

Pub. Date : 2011 May 15

PMID : 21459798






1 Functional Relationships(s)
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1 All these changes lead to increased activation of Bax and Bak, loss of the mitochondrial membrane potential, cytochrome c release, caspase activation, and caspase-dependent apoptosis on treatment with bortezomib and TRAIL. Bortezomib BCL2 associated X, apoptosis regulator Homo sapiens