Pub. Date : 2011 May
PMID : 21456632
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sex differences in 3,4-methylenedioxymethamphetamine (MDMA; ecstasy)-induced cytochrome P450 2D6 inhibition in humans. | N-Methyl-3,4-methylenedioxyamphetamine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 2 | Sex differences in 3,4-methylenedioxymethamphetamine (MDMA; ecstasy)-induced cytochrome P450 2D6 inhibition in humans. | N-Methyl-3,4-methylenedioxyamphetamine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 3 | Sex differences in 3,4-methylenedioxymethamphetamine (MDMA; ecstasy)-induced cytochrome P450 2D6 inhibition in humans. | N-Methyl-3,4-methylenedioxyamphetamine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 4 | This study assessed the inhibition and recovery half-life of CYP2D6 and CYP3A4 activity in female subjects by administering the probe drug dextromethorphan before and repeatedly after MDMA administration. | N-Methyl-3,4-methylenedioxyamphetamine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 5 | In women, MDMA use has been associated with psychiatric symptoms and psychological problems that may require psychopharmacological treatment with antidepressant drugs, some of which are known CYP2D6 substrates. | N-Methyl-3,4-methylenedioxyamphetamine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 6 | MDMA-induced mechanism-based inhibition of CYP2D6 is of relevance, and physicians should be advised to prescribe medications whose metabolic disposition is not regulated by CYP2D6. | N-Methyl-3,4-methylenedioxyamphetamine | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |