Title : Citrullination of inhibitor of growth 4 (ING4) by peptidylarginine deminase 4 (PAD4) disrupts the interaction between ING4 and p53.

Pub. Date : 2011 May 13

PMID : 21454715






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 A citrulline-mimicking Arg-NLS-Gln ING4 mutant, which has all Arg residues in the NLS mutated to Gln, loses its affinity for p53, can no longer promote p53 acetylation, and results in repression of downstream p21 expression. Glutamine tumor protein p53 Homo sapiens
2 A citrulline-mimicking Arg-NLS-Gln ING4 mutant, which has all Arg residues in the NLS mutated to Gln, loses its affinity for p53, can no longer promote p53 acetylation, and results in repression of downstream p21 expression. Glutamine tumor protein p53 Homo sapiens