Pub. Date : 2011 May 20
PMID : 21454520
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mutant p53 protein is targeted by arsenic for degradation and plays a role in arsenic-mediated growth suppression. | Arsenic | tumor protein p53 | Homo sapiens |
| 2 | Mutant p53 protein is targeted by arsenic for degradation and plays a role in arsenic-mediated growth suppression. | Arsenic | tumor protein p53 | Homo sapiens |
| 3 | Interestingly, wild type p53 is accumulated in cells treated with arsenic compounds, presumably due to arsenic-induced oxidative stresses. | Arsenic | tumor protein p53 | Homo sapiens |
| 4 | Interestingly, wild type p53 is accumulated in cells treated with arsenic compounds, presumably due to arsenic-induced oxidative stresses. | Arsenic | tumor protein p53 | Homo sapiens |
| 5 | In contrast, we found that arsenic compounds degrade both endogenous and ectopically expressed mutant p53 in time- and dose-dependent manners. | Arsenic | tumor protein p53 | Homo sapiens |
| 6 | We also found that arsenic trioxide decreases the stability of mutant p53 protein through a proteasomal pathway, and blockage of mutant p53 nuclear export can alleviate the arsenic-induced mutant p53 degradation. | Arsenic | tumor protein p53 | Homo sapiens |
| 7 | Taken together, we found that mutant p53 is a target of arsenic compounds, which provides an insight into exploring arsenic compound-based therapy for tumors harboring a mutant p53. | Arsenic | tumor protein p53 | Homo sapiens |
| 8 | Taken together, we found that mutant p53 is a target of arsenic compounds, which provides an insight into exploring arsenic compound-based therapy for tumors harboring a mutant p53. | Arsenic | tumor protein p53 | Homo sapiens |
| 9 | Taken together, we found that mutant p53 is a target of arsenic compounds, which provides an insight into exploring arsenic compound-based therapy for tumors harboring a mutant p53. | Arsenic | tumor protein p53 | Homo sapiens |
| 10 | Taken together, we found that mutant p53 is a target of arsenic compounds, which provides an insight into exploring arsenic compound-based therapy for tumors harboring a mutant p53. | Arsenic | tumor protein p53 | Homo sapiens |