Pub. Date : 2012 Feb
PMID : 21435178
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Methamphetamine alters occludin expression via NADPH oxidase-induced oxidative insult and intact caveolae. | Methamphetamine | occludin | Homo sapiens |
| 2 | Inhibition of NOX by NSC 23766 attenuated METH-induced ROS generation, changes in occludin protein levels and monocyte migration. | Methamphetamine | occludin | Homo sapiens |
| 3 | Inhibition of ERK1/2 activity or caveolin-1 silencing protected against METH-induced alterations of occludin levels. | Methamphetamine | occludin | Homo sapiens |
| 4 | These findings indicate an important role of NOX and functional caveolae in METH-induced oxidative stress in brain endothelial cells that contribute to the subsequent alterations of occludin levels and transendothelial migration of inflammatory cells. | Methamphetamine | occludin | Homo sapiens |