Title : Intracellular inhibition of mono(ADP-ribosylation) by meta-iodobenzylguanidine: specificity, intracellular concentration and effects on glucocorticoid-mediated cell lysis.

Pub. Date : 1990 Aug 13

PMID : 2143421






3 Functional Relationships(s)
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1 Conversely, mono-ADPRT was inhibited by MIBG (IC50 = approx. 3-Iodobenzylguanidine ADP-ribosyltransferase 1 Mus musculus
2 Inhibition of endogenous mono-ADPRT with 0.03 mM MIBG or 10 mM nicotinamide induced sensitivity to glucocorticoids in refractory L1210-wt cells. 3-Iodobenzylguanidine ADP-ribosyltransferase 1 Mus musculus
3 These results indicate that MIBG is the first substrate for guanidino-specific mono-ADPRT which accumulates in intact mammalian cells and effectively competes with intracellular acceptors for endogenous enzymes. 3-Iodobenzylguanidine ADP-ribosyltransferase 1 Mus musculus