Title : Short- and long-term exposure of articular cartilage to curcumin or quercetin inhibits aggrecan loss.

Pub. Date : 2012 Feb

PMID : 21419610






2 Functional Relationships(s)
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1 Quercetin suppressed IL-1alpha-stimulated expression of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-4. Quercetin ADAM metallopeptidase with thrombospondin type 1 motif 4 Bos taurus
2 The ability of curcumin and quercetin to protect cartilage from stimulated aggrecan loss and to maintain this protection posttreatment may, at least in part, be due to the suppression of gene expression of ADAMTS-4 and -5. Quercetin ADAM metallopeptidase with thrombospondin type 1 motif 4 Bos taurus