Title : Effects of ethanol on transforming growth factor Β1-dependent and -independent mechanisms of neural stem cell apoptosis.

Pub. Date : 2011 Jun

PMID : 21419121






3 Functional Relationships(s)
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1 A quantitative polymerase chain reaction array of apoptosis-related mRNAs revealed an ethanol-induced increase (>=2-fold change; p<0.05) in transcripts involved in Fas ligand (FasL) and tumor necrosis factor (TNF) signaling. Ethanol tumor necrosis factor Homo sapiens
2 A quantitative polymerase chain reaction array of apoptosis-related mRNAs revealed an ethanol-induced increase (>=2-fold change; p<0.05) in transcripts involved in Fas ligand (FasL) and tumor necrosis factor (TNF) signaling. Ethanol tumor necrosis factor Homo sapiens
3 Thus, ethanol induces NSC death through two distinct molecular mechanisms, one is initiated by TGFbeta1 (FasL) and another (through TNF) which is TGFbeta1-independent. Ethanol tumor necrosis factor Homo sapiens