Title : Mechanism-based inhibition of cytochrome P450 (CYP)2A6 by chalepensin in recombinant systems, in human liver microsomes and in mice in vivo.

Pub. Date : 2011 Jul

PMID : 21418183






1 Functional Relationships(s)
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1 This time-dependent inactivation (k(inact) 0.044 min(-1) ; K(I) 2.64 microM) caused the loss of spectrally detectable P450 content and was diminished by known inhibitors of CYP2A6, pilocarpine or tranylcypromine, and by glutathione conjugation. Tranylcypromine cytochrome P450 family 2 subfamily A member 6 Homo sapiens