Title : Oxime amides as a novel zinc binding group in histone deacetylase inhibitors: synthesis, biological activity, and computational evaluation.

Pub. Date : 2011 Apr 14

PMID : 21417297






1 Functional Relationships(s)
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1 These somehow contradictory results were finally rationalized by a computational assisted SAR, which gave us the chance to understand how the oxime derivatives interact with the catalytic site and justify the observed activity profile. Oximes sarcosine dehydrogenase Homo sapiens