Title : Modulation of membrane-bound glutathione transferase activity by phospholipids including cardiolipin.

Pub. Date : 2011

PMID : 21415529






6 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Membrane-bound glutathione transferases (MGST1) distributed mostly in liver microsomal and mitochondrial membranes are activated by the thiol modification. Sulfhydryl Compounds microsomal glutathione S-transferase 1 Homo sapiens
2 Although MGST1 was activated by the thiol alkylation with N-ethylmaleimide (NEM), the activation was suppressed in the presence of anionic phospholipids as clearly observed in the presence of CL. Sulfhydryl Compounds microsomal glutathione S-transferase 1 Homo sapiens
3 These results indicate that reactivity (stability) of the thiol in MGST1 is affected by surrounding lipids, namely CL which prevents MGST1 activation by thiol modification. Sulfhydryl Compounds microsomal glutathione S-transferase 1 Homo sapiens
4 These results indicate that reactivity (stability) of the thiol in MGST1 is affected by surrounding lipids, namely CL which prevents MGST1 activation by thiol modification. Sulfhydryl Compounds microsomal glutathione S-transferase 1 Homo sapiens
5 These results indicate that reactivity (stability) of the thiol in MGST1 is affected by surrounding lipids, namely CL which prevents MGST1 activation by thiol modification. Sulfhydryl Compounds microsomal glutathione S-transferase 1 Homo sapiens
6 These results indicate that reactivity (stability) of the thiol in MGST1 is affected by surrounding lipids, namely CL which prevents MGST1 activation by thiol modification. Sulfhydryl Compounds microsomal glutathione S-transferase 1 Homo sapiens