Title : Dual mTORC2/mTORC1 targeting results in potent suppressive effects on acute myeloid leukemia (AML) progenitors.

Pub. Date : 2011 Jul 1

PMID : 21415215






1 Functional Relationships(s)
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1 Inhibition of the mTOR catalytic site with OSI-027 results in suppression of both mTORC2 and RI-mTORC1 complexes and elicits much more potent antileukemic responses than selective mTORC1 targeting with rapamycin. OSI 027 CREB regulated transcription coactivator 1 Mus musculus