Title : Monoclonal antibodies targeting IL-1 beta reduce biomarkers of atherosclerosis in vitro and inhibit atherosclerotic plaque formation in Apolipoprotein E-deficient mice.

Pub. Date : 2011 Jun

PMID : 21411094






1 Functional Relationships(s)
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1 This effect was comparable to that reported for complete genetic ablation of IL-1beta or IL-1R1 on an ApoE(-/-) background and was associated with decreases in plasma non-HDL/HDL cholesterol ratio and plaque lipid content and macrophage infiltration. Cholesterol interleukin 1 beta Mus musculus