Title : Biochemical characterization of human HIF hydroxylases using HIF protein substrates that contain all three hydroxylation sites.

Pub. Date : 2011 Jun 1

PMID : 21410436






1 Functional Relationships(s)
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1 HIF proteins are regulated by three Fe(II)- and alpha-KG (alpha-ketoglutarate)-dependent prolyl hydroxylase enzymes [PHD (prolyl hydroxylase domain) isoenzymes 1-3 or PHD1, PHD2 and PHD3] and one asparaginyl hydroxylase [FIH (factor inhibiting HIF)]. Ketoglutaric Acids egl-9 family hypoxia inducible factor 1 Homo sapiens