Title : DNAM-1 ligand expression on Ag-stimulated T lymphocytes is mediated by ROS-dependent activation of DNA-damage response: relevance for NK-T cell interaction.

Pub. Date : 2011 May 5

PMID : 21406724






1 Functional Relationships(s)
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1 The up-regulation of PVR expression involves DNA-damage response (DDR)-dependent pathways, because we found that pharmacologic inhibition of ATM and ATR kinases reduced PVR expression and that PVR was almost exclusively induced on cells expressing the DDR marker gammaH2AX. gammah2ax ATM serine/threonine kinase Homo sapiens