Title : Overcoming temozolomide resistance in glioblastoma via dual inhibition of NAD+ biosynthesis and base excision repair.

Pub. Date : 2011 Mar 15

PMID : 21406402






1 Functional Relationships(s)
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1 Importantly, we find that the combination of BER and NAD(+) biosynthesis inhibition significantly sensitizes glioma cells with elevated expression of MGMT and those deficient in MMR, two genotypes normally associated with TMZ resistance. NAD O-6-methylguanine-DNA methyltransferase Homo sapiens