Pub. Date : 2011 Feb
PMID : 21403839
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Intervening in beta-catenin signaling by sulindac inhibits S100A4-dependent colon cancer metastasis. | Sulindac | catenin (cadherin associated protein), beta 1 | Mus musculus |
| 2 | We treated colon cancer cell lines heterozygous for gain-of-function and wild-type beta-catenin with sulindac. | Sulindac | catenin (cadherin associated protein), beta 1 | Mus musculus |
| 3 | We report the expression knockdown of beta-catenin by sulindac, leading to its reduced nuclear accumulation. | Sulindac | catenin (cadherin associated protein), beta 1 | Mus musculus |
| 4 | Splenic tumors and liver metastases of sulindac-treated mice showed lowered beta-catenin and S100A4 levels. | Sulindac | catenin (cadherin associated protein), beta 1 | Mus musculus |
| 5 | These results suggest that modulators of beta-catenin signaling such as sulindac offer potential as antimetastatic agents by interdicting S100A4 expression. | Sulindac | catenin (cadherin associated protein), beta 1 | Mus musculus |