Title : 5'-Nitro-indirubinoxime inhibits epidermal growth factor- and phorbol ester-induced AP-1 activity and cell transformation through inhibition of phosphorylation of Pin1.

Pub. Date : 2011 Dec

PMID : 21400615






3 Functional Relationships(s)
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1 Western blot analysis revealed that 5"-NIO inhibited activities of Raf-1 (S338), MEK1/2, ERK1/2, JNK, and c-Jun induced by EGF or TPA, respectively, whereas it did not affect autophosphorylation of epidermal growth factor receptor (EGFR) induced by EGF or TPA. Tetradecanoylphorbol Acetate v-raf-leukemia viral oncogene 1 Mus musculus
2 Importantly, 5"-NIO inhibited Pin1 phosphorylation at serine 16 induced by EGF or TPA, respectively, resulted in the inhibition of interaction between Pin1 and Raf-1. Tetradecanoylphorbol Acetate v-raf-leukemia viral oncogene 1 Mus musculus
3 Together, these findings suggest that 5"-NIO might act as an anticarcinogene in EGF- or TPA-induced carcinogenesis through the inhibition of interaction between Pin1 and Raf-1. Tetradecanoylphorbol Acetate v-raf-leukemia viral oncogene 1 Mus musculus