Title : 5'-Nitro-indirubinoxime inhibits epidermal growth factor- and phorbol ester-induced AP-1 activity and cell transformation through inhibition of phosphorylation of Pin1.

Pub. Date : 2011 Dec

PMID : 21400615






1 Functional Relationships(s)
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1 Western blot analysis revealed that 5"-NIO inhibited activities of Raf-1 (S338), MEK1/2, ERK1/2, JNK, and c-Jun induced by EGF or TPA, respectively, whereas it did not affect autophosphorylation of epidermal growth factor receptor (EGFR) induced by EGF or TPA. Tetradecanoylphorbol Acetate mitogen-activated protein kinase 3 Mus musculus