Title : Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1β and tumor necrosis factor α.

Pub. Date : 2011 Jul

PMID : 21400477






1 Functional Relationships(s)
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1 Procatabolic responses to IL-1beta and TNFalpha, such as release of glycosaminoglycan, nitric oxide, and matrix metalloproteinases 3 and 13 were determined by dimethylmethylene blue assay, Griess reaction, and Western blotting, respectively, in cartilage explants and chondrocytes with and without knockdown of AMPKalpha by small interfering RNA. Glycosaminoglycans interleukin 1 beta Homo sapiens