Title : Preclinical evaluation of the antitumor activity of bortezomib in combination with vitamin C or with epigallocatechin gallate, a component of green tea.

Pub. Date : 2011 Nov

PMID : 21400028






2 Functional Relationships(s)
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1 However, when combined with EGCG such that the plasma concentrations of EGCG were >200 muM at the time of bortezomib dosing, all antitumor activity was abrogated (TGI = -17.7%). epigallocatechin gallate latexin Homo sapiens
2 A lower concentration of EGCG (11-16 muM), which is severalfold higher than measured clinically in humans taking EGCG supplements (0.6-3 muM), was not antagonistic to bortezomib (TGI 63.5%). epigallocatechin gallate latexin Homo sapiens