Title : Synthesis, biological evaluation and molecular modeling of novel triazole-containing berberine derivatives as acetylcholinesterase and β-amyloid aggregation inhibitors.

Pub. Date : 2011 Apr 1

PMID : 21397508






2 Functional Relationships(s)
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1 Synthesis, biological evaluation and molecular modeling of novel triazole-containing berberine derivatives as acetylcholinesterase and beta-amyloid aggregation inhibitors. Berberine acetylcholinesterase (Cartwright blood group) Homo sapiens
2 Molecular modeling studies indicated that the triazole moiety of berberine derivatives displayed a face-to-face pi-pi stacking interaction in a "sandwich" form with the Trp84 (4.09 A) and Phe330 (4.33 A) in catalytic sites of AChE. Berberine acetylcholinesterase (Cartwright blood group) Homo sapiens