Title : Hydrogen sulfide is a partially redox-independent activator of the human jejunum Na+ channel, Nav1.5.

Pub. Date : 2011 Jun

PMID : 21393430






2 Functional Relationships(s)
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1 The aims of this study were to determine the effects of the H(2)S donor NaHS on Na(V)1.5, a voltage-dependent sodium channel expressed in the gastrointestinal tract in human jejunum smooth muscle cells and interstitial cells of Cajal, and to elucidate whether H(2)S acts on Na(V)1.5 by redox reactions. sodium bisulfide immunoglobulin lambda variable 2-18 Homo sapiens
2 Pretreatment with the Hg(2+)-conjugated oxidizer thimerosal or the alkylating agent N-ethylmaleimide inhibited or decreased NaHS induction of Na(V)1.5 peak current. sodium bisulfide immunoglobulin lambda variable 2-18 Homo sapiens