Title : Critical roles of interactions among switch I-preceding residues and between switch II and its neighboring alpha-helix in conformational dynamics of the GTP-bound Ras family small GTPases.

Pub. Date : 2011 Apr 29

PMID : 21388959






2 Functional Relationships(s)
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1 Comparison among the two structures and other state 1 and state 2 structures of H-Ras/M-Ras reveal two new structural features playing critical roles in state dynamics; interaction of residues 31/41 (H-Ras/M-Ras) with residues 29/39 and 30/40, which induces a conformational change of switch I favoring its interaction with the gamma-phosphate, and the hydrogen-bonding interaction of switch II with its neighboring alpha-helix, alpha3-helix, which induces a conformational change of switch II favoring its interaction with the gamma-phosphate. gamma-phosphate muscle RAS oncogene homolog Homo sapiens
2 Comparison among the two structures and other state 1 and state 2 structures of H-Ras/M-Ras reveal two new structural features playing critical roles in state dynamics; interaction of residues 31/41 (H-Ras/M-Ras) with residues 29/39 and 30/40, which induces a conformational change of switch I favoring its interaction with the gamma-phosphate, and the hydrogen-bonding interaction of switch II with its neighboring alpha-helix, alpha3-helix, which induces a conformational change of switch II favoring its interaction with the gamma-phosphate. gamma-phosphate muscle RAS oncogene homolog Homo sapiens