Title : Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors.

Pub. Date : 2011 Apr 1

PMID : 21388807






1 Functional Relationships(s)
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1 This Letter describes the de novo design of non-peptidic hydroxyethylamine (HEA) inhibitors of BACE-1 by elimination of P-gp contributing amide attachments. hea phosphoglycolate phosphatase Homo sapiens