Title : Possible role of propofol's cyclooxygenase-inhibiting property in alleviating dopaminergic neuronal loss in the substantia nigra in an MPTP-induced murine model of Parkinson's disease.

Pub. Date : 2011 Apr 28

PMID : 21376018






1 Functional Relationships(s)
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1 The number of dopaminergic neurons in the SNpc was significantly reduced by MPTP treatment, while the MPTP-induced neuronal loss was minimal upon treatment with propofol or the selective COX-2 inhibitor, NS-398. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine cytochrome c oxidase II, mitochondrial Mus musculus