Title : RRM1 gene expression in peripheral blood is predictive of shorter survival in Chinese patients with advanced non-small-cell lung cancer treated by gemcitabine and platinum.

Pub. Date : 2011 Mar

PMID : 21370501






4 Functional Relationships(s)
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1 RRM1 gene expression in peripheral blood is predictive of shorter survival in Chinese patients with advanced non-small-cell lung cancer treated by gemcitabine and platinum. Platinum ribonucleotide reductase catalytic subunit M1 Homo sapiens
2 OBJECTIVE: To evaluate the predictive values of gene expressions of ribonucleotide reductase M1 (RRM1) and breast cancer susceptibility gene 1 (BRCA1) in peripheral blood from Chinese patients with non-small-cell lung cancer (NSCLC) treated with gemcitabine plus platinum. Platinum ribonucleotide reductase catalytic subunit M1 Homo sapiens
3 Advanced NSCLC patients with low RRM1 expression levels may benefit from gemcitabine plus platinum therapy. Platinum ribonucleotide reductase catalytic subunit M1 Homo sapiens
4 RRM1 mRNA expression in peripheral blood could be used to predict the prognosis of NSCLC treated by gemcitabine and platinum. Platinum ribonucleotide reductase catalytic subunit M1 Homo sapiens