Title : Fenofibric acid prevents retinal pigment epithelium disruption induced by interleukin-1β by suppressing AMP-activated protein kinase (AMPK) activation.

Pub. Date : 2011 Jun

PMID : 21369818






5 Functional Relationships(s)
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1 Fenofibric acid prevents retinal pigment epithelium disruption induced by interleukin-1beta by suppressing AMP-activated protein kinase (AMPK) activation. fenofibric acid interleukin 1 beta Homo sapiens
2 RESULTS: Treatment of ARPE-19 cells with fenofibric acid significantly reduced the increment of permeability and the breakdown of the ARPE-19 cell monolayer induced by D-glucose, 25 mmol/l, and IL-1beta, 10 ng/ml, in a dose-dependent manner. fenofibric acid interleukin 1 beta Homo sapiens
3 Fenofibric acid prevented the activation of AMPK induced by IL-1beta and the hyperpermeability induced by IL-1beta was blocked by silencing AMPK. fenofibric acid interleukin 1 beta Homo sapiens
4 Fenofibric acid prevented the activation of AMPK induced by IL-1beta and the hyperpermeability induced by IL-1beta was blocked by silencing AMPK. fenofibric acid interleukin 1 beta Homo sapiens
5 CONCLUSIONS/INTERPRETATION: Disruption of RPE induced by IL-1beta is prevented by fenofibric acid through its ability to suppress AMPK activation. fenofibric acid interleukin 1 beta Homo sapiens