Pub. Date : 2011 May
PMID : 21364010
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | hTERT promotes imatinib resistance in chronic myeloid leukemia cells: therapeutic implications. | Imatinib Mesylate | telomerase reverse transcriptase | Homo sapiens |
| 2 | We showed that sensitivity to imatinib can be partly restored in imatinib-resistant cells by targeting telomerase expression, either by the introduction of a dominant-negative form of the catalytic protein subunit of the telomerase (hTERT) or by the treatment with all-trans-retinoic acid, a clinically used drug. | Imatinib Mesylate | telomerase reverse transcriptase | Homo sapiens |
| 3 | Furthermore, we showed that hTERT overexpression favors the development of imatinib resistance through both its antiapoptotic and telomere maintenance functions. | Imatinib Mesylate | telomerase reverse transcriptase | Homo sapiens |