Title : Reduced VEGF production, angiogenesis, and vascular regrowth contribute to the antitumor properties of dual mTORC1/mTORC2 inhibitors.

Pub. Date : 2011 Mar 1

PMID : 21363918






1 Functional Relationships(s)
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Protein Name
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1 ATP-competitive inhibitors OSI-027 and OXA-01 targeted both mTORC1 and mTORC2 signaling in vitro and in vivo, unlike rapamycin that only inhibited mTORC1 signaling. OSI 027 CREB regulated transcription coactivator 1 Mus musculus