Title : Hepatic autophagy mediates endoplasmic reticulum stress-induced degradation of misfolded apolipoprotein B.

Pub. Date : 2011 May

PMID : 21360721






1 Functional Relationships(s)
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1 Treatment of McA-RH7777 cells with 4-phenyl butyric acid, a chemical ER stress inhibitor, prevented glucosamine- and tunicamycin-induced increases in GRP78 and phosphorylated eIF2alpha, rescued newly synthesized [(35) S]-labeled apoB100, and substantially blocked the colocalization of apoB with GFP-LC3. Tunicamycin eukaryotic translation initiation factor 2A Rattus norvegicus