Title : Potent inhibition of human cytochrome P450 3A isoforms by cannabidiol: role of phenolic hydroxyl groups in the resorcinol moiety.

Pub. Date : 2011 Apr 11

PMID : 21356216






3 Functional Relationships(s)
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Protein Name
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1 For CYP3A7, Delta(9)-THC, CBD, and CBN inhibited the activity to a similar extent (IC(50)=23-31 muM). Cannabidiol latexin Homo sapiens
2 CBD competitively inhibited the activity of CYP3A4, CYP3A5, and HLMs (K(i)=1.00, 0.195, and 6.14 muM, respectively). Cannabidiol latexin Homo sapiens
3 On the other hand, CBD inhibited the CYP3A7 activity in a mixed manner (K(i)=12.3 muM). Cannabidiol latexin Homo sapiens