Title : Structure-activity relationship study of 2,4-diaminothiazoles as Cdk5/p25 kinase inhibitors.

Pub. Date : 2011 Apr 1

PMID : 21353545






1 Functional Relationships(s)
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1 A structure-activity relationship study of 2,4-diaminothiazole inhibitors revealed that increased Cdk5/p25 inhibitory activity could be accomplished by incorporating pyridines on the 2-amino group and addition of substituents to the 2- or 3-position of the phenyl ketone moiety. Pyridines cyclin-dependent kinase 5, regulatory subunit 1 (p35) Mus musculus