Title : Vitamin K enhancement of sorafenib-mediated HCC cell growth inhibition in vitro and in vivo.

Pub. Date : 2010 Dec 15

PMID : 21351273






2 Functional Relationships(s)
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1 Thus, combination of VK1 plus sorafenib strongly induced growth inhibition and apoptosis in rodent and human HCC and inhibited the RAF/mitogen-activated protein kinase kinase/ERK pathway. Sorafenib zinc fingers and homeoboxes 2 Homo sapiens
2 Thus, each agent can antagonize Raf: sorafenib as a direct inhibitor and VK1 through inhibitory Raf phosphorylation. Sorafenib zinc fingers and homeoboxes 2 Homo sapiens