Title : Interactive effect of angiotensin II type 1 receptor (AGT1R) polymorphisms and plasma irbesartan concentration on antihypertensive therapeutic responses to irbesartan.

Pub. Date : 2011 May

PMID : 21346624






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 RESULTS: When stratified by genotypes, patients carrying allele C of single-neucleotide polymorphism (SNP) rs5186 showed positive association between irbesartan concentration and BP response [SBP: beta +- SE=6.1 +- 2.3 with false discovery rate (FDR) P=0.029; DBP: beta +- SE=2.7 +- 1.0 with FDR P=0.029], but this was not seen in patients with AA genotype. Irbesartan selenium binding protein 1 Homo sapiens
2 There was a significant interaction between plasma irbesartan concentration and SNP rs5186 on SBP response (interaction P=0.0335) and DBP response (interaction P=0.0190). Irbesartan selenium binding protein 1 Homo sapiens
3 There also were significant interactions between plasma irbesartan concentration and hap3, hap5 and hap6 (constructed by four genotyped SNPs) on SBP response (FDR P<0.001), but not on DBP response. Irbesartan selenium binding protein 1 Homo sapiens