Title : TET inducible expression of the α4β7-integrin ligand MAdCAM-1 on the blood-brain barrier does not influence the immunopathogenesis of experimental autoimmune encephalomyelitis.

Pub. Date : 2011 Mar

PMID : 21341265






3 Functional Relationships(s)
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1 TET inducible expression of the alpha4beta7-integrin ligand MAdCAM-1 on the blood-brain barrier does not influence the immunopathogenesis of experimental autoimmune encephalomyelitis. Tetracycline mucosal vascular addressin cell adhesion molecule 1 Mus musculus
2 Although TET-regulated MAdCAM-1 induced alpha4beta7-integrin mediated interaction of alpha4beta7(+) /alpha4beta1(-) T cells with the BBB in vitro and in vivo, it failed to influence EAE pathogenesis in C57BL/6 mice. Tetracycline mucosal vascular addressin cell adhesion molecule 1 Mus musculus
3 TET-regulated MAdCAM-1 on the BBB neither changed the localization of central nervous system (CNS) perivascular inflammatory cuffs nor did it enhance the percentage of alpha4beta7-integrin(+) inflammatory cells within the CNS during EAE. Tetracycline mucosal vascular addressin cell adhesion molecule 1 Mus musculus