Title : Carcinoma-associated fibroblasts promotes the proliferation of a lingual carcinoma cell line by secreting keratinocyte growth factor.

Pub. Date : 2011 Jun

PMID : 21340484






4 Functional Relationships(s)
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1 The results showed that oral CAFs secreted a higher level of KGF than oral normal fibroblasts (NFs), and the conditioned medium of CAFs could increase the viability of carcinoma cells and promote more of them into G2 and S phase. cafs fibroblast growth factor 7 Homo sapiens
2 The results showed that oral CAFs secreted a higher level of KGF than oral normal fibroblasts (NFs), and the conditioned medium of CAFs could increase the viability of carcinoma cells and promote more of them into G2 and S phase. cafs fibroblast growth factor 7 Homo sapiens
3 However, after blocking with KGF antibody, the viability and cell cycle of Tca8113 cultured with CAFs conditioned medium changed to be similar with NFs control groups. cafs fibroblast growth factor 7 Homo sapiens
4 It was concluded that CAFs could promote the proliferation of OSCC through secreting high levels of KGF. cafs fibroblast growth factor 7 Homo sapiens